Transplantation Genomics

The Transplantation genomics research project is subdivided into two major subprojects described below:

Whole genome histocompatibility and Utilization of genome data.

The project PI is Jukka Partanen, with co-PIs Kati Hyvärinen and Jarmo Ritari.

To ensure strong clinical impact, these studies are conducted in a close collaboration with Finnish transplantation clinicians and the HLA laboratory of the Blood Service.

Large and well-curated study cohorts are fundamental for generating reliable scientific results. We currently have genome and phenotype data from over 1300 stem cell transplantations and ~1000 kidney and ~800 liver transplantations done in Finland. Additional non-Finnish cohorts are also included in our analyses. As partners in the iGeneTRAiN consortium, we have results of genome-wide association studies from over 15 000 kidney transplantations worldwide.