Articles 2024

Clancy J, Ritari J, Vaittinen E, Arvas M, Tammi S; FinnGen; Koskela S, Partanen J. Blood donor biobank as a resource in personalised biomedical genetic research. Eur J Hum Genet. 2024 Jan 12. Epub ahead of print. PMID: 38212662.

Bulanova D, Akimov Y, Senkowski W, Oikkonen J, Gall-Mas L, Timonen S, Elmadani M, Hynninen J, Hautaniemi S, Aittokallio T, Wennerberg K. A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells. Sci Adv. 2024 May 24;10(21):eadj1564. Epub 2024 May 23. PMID: 38781347.

Helanterä I, Dörje C, Ortiz F, Varberg Reisæter A, Hammarström C, Lauronen J, Räisänen-Sokolowski A, Haugen AJ, Lempinen M, Åsberg A, Mjøen G. Very Low Frequency of Pathological Findings in One-year Protocol Biopsies of Uneventful Standard Risk Kidney Transplant Recipients: Results From the Nordic Protocol Biopsy Study. Transplant Direct. 2024 Apr 11;10(5):e1621. PMID: 38617466.

Hyvärinen K, Haimila K, Moslemi C, Biobank BS, Olsson ML, Ostrowski SR, Pedersen OB, Erikstrup C, Partanen J, Ritari J. A machine-learning method for biobank-scale genetic prediction of blood group antigens. PLoS Comput Biol. 2024 Mar 21;20(3):e1011977. Epub ahead of print. PMID: 38512997.

Ilmakunnas M, Koivusalo L, Okkonen M. Verensiirtoreaktiot. Duodecim 2024;140:121-9. https://www.duodecimlehti.fi/duo18073

Jahnukainen T, Sareneva I, Lauronen J, Ylinen E, Tainio J, Nordin A, Hukkinen M, Pakarinen MP, Jalanko H. A Retrospective Study of Long-Term Outcomes in 16 ABO-Incompatible Deceased Donor Pediatric Liver Transplants from a National Transplant Center at Helsinki University Hospital, Finland, 1987-2022. Ann Transplant. 2024 Feb 13;29:e941929. PMID: 38347714.

Jama T, Lefering R, Lauronen J, Handolin L. Factors affecting physicians’ decision to start prehospital blood product transfusion in blunt trauma patients: A cohort study of Helsinki Trauma Registry. Transfusion. 2024 May;64 Suppl 2:S167-S173. PMID: 38511866.

Karregat JHM, Ekroos S, Castrén J, Arvas M, van den Hurk K. Iron status in Dutch and Finnish blood donor and general populations: A cross-cohort comparison study. Vox Sang. 2024 Apr 15. Epub ahead of print. PMID: 38622934.

Khawaja T, Kajova M, Levonen I, Pietilä JP, Välimaa H, Paajanen J, Pakkanen SH, Patjas A, Montonen R, Miettinen S, Virtanen J, Smura T, Sironen T, Fagerlund R, Ugurlu H, Iheozor-Ejiofor R, Saksela K, Vahlberg T, Ranki A, Vierikko A, Ihalainen J, Vapalahti O, Kantele A. Double-blinded, randomised, placebo-controlled trial of convalescent plasma for COVID-19: analyses by neutralising antibodies homologous to donors’ variants. Infect Dis (Lond). 2024 Mar 21:1-11. Epub ahead of print. PMID: 38513074.

Koivunotko E, Koivuniemi R, Monola J, Harjumäki R, Pridgeon CS, Madetoja M, Linden J, Paasonen L, Laitinen S, Yliperttula M. Cellulase-assisted platelet-rich plasma release from nanofibrillated cellulose hydrogel enhances wound healing. J Control Release. 2024 Apr;368:397-412. PMID: 38423475.

Lehikoinen J, Nurmi K, Ainola M, Clancy J, Nieminen JK, Jansson L, Vauhkonen H, Vaheri A, Smura T, Laakso SM, Eklund KK, Tienari PJ. Epstein-Barr Virus in the Cerebrospinal Fluid and Blood Compartments of Patients With Multiple Sclerosis and Controls. Neurol Neuroimmunol Neuroinflamm. 2024 May;11(3):e200226. Epub 2024 Apr 12. PMID: 38608226.

Meulenbeld A, Toivonen J, Vinkenoog M, Brits T, Swanevelder R, de Clippel D, Compernolle V, Karki S, Welvaert M, van den Hurk K, van Rosmalen J, Lesaffre E, Janssen M, Arvas M. Predicting haemoglobin deferral using machine learning models: Can we use the same prediction model across countries? Vox Sang. 2024 Apr 18. Epub ahead of print. PMID: 38637123.

Nihtilä J, Salmenniemi U, Itälä-Remes M, Crossland RE, Gallardo D, Bogunia-Kubik K, Łacina P, Bieniaszewska M, Giebel S, Hyvärinen K, Kekäläinen E, Ritari J, Partanen J. Donor genetic determinant of thymopoiesis, rs2204985, and stem cell transplantation outcome in a multipopulation cohort. Hum Immunol. 2024 Mar 28:110791. Epub ahead of print. PMID: 38553383.

Peltola M, Kaukinen K, Basnyat P, Raitanen J, Haimila K, Liimatainen S, Rainesalo S, Peltola J. Hippocampal sclerosis is associated with celiac disease type immunity in patients with drug-resistant temporal lobe epilepsy. J Neurol. 2024 May;271(5):2596-2604. PMID: 38337123.

Raivola V, Thorpe R. A scoping review of sociology of voluntary blood donation. Vox Sang. 2024 Apr 30. Online ahead of print.  PMID: 38686587.

Reeve MP, Vehviläinen M, Luo S, Ritari J, Karjalainen J, Gracia-Tabuenca J, Mehtonen J, Padmanabhuni SS, Kolosov N, Artomov M, Siirtola H, Olilla HM; FinnGen; Graham D, Partanen J, Xavier RJ, Daly MJ, Ripatti S, Salo T, Siponen M. Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer. Am J Hum Genet. 2024 May 15:S0002-9297(24)00161-7. Epub ahead of print. PMID: 38776927.

Susila S, Ilmakunnas M, Lauronen J, Vuorinen P, Ångerman S, Sainio S. Low titer group O whole blood and risk of RhD alloimmunization: Rationale for use in Finland. Transfusion. 2024 May;64 Suppl 2:S119-S125. PMID: 38240146.

Thorpe R, Raivola V, Masser B. Recoding the gift relationship: views on introducing genomic testing to blood donation. New Genetics and Society. 2024 43:1. DOI: 10.1080/14636778.2024.2317709

Yazer MH, Werneiwski K, Thompson P, Titlestad K, Watkins T, Smith S, Bengtsson J, Brunetta DM, Carlos L, Jenkins D, Salcido J, Ngamsuntikul SG, Taye H, Kinfu A, Tadesse D, Jackson BP, Kutner J, Yokoyama AP, Hess JR, Tuott E, Ilmakunnas M, de Regt AK, Wiebke H, Seltsam A, Braverman M, Compton F, Sutor L, Meledeo MA, Messenger JM, DePasquale M. Novel method for determining when a field-collected donor unit is sufficiently full. Transfusion. 2024 May;64 Suppl 2:S27-S33. PMID: 38251751.

Consortium publications

Aaramaa HK, Mars N, Helminen M, Kerola AM, Palomäki A, Eklund KK, Gracia-Tabuenca J, Sinisalo J, FinnGen, Isomäki P. Risk of cardiovascular comorbidities before and after the onset of rheumatic diseases. Semin Arthritis Rheum. 2024 Jan 26;65:152382. Epub ahead of print. PMID: 38308930.

Broberg M, Ampuja M, Jones S, Ojala T, Rahkonen O, Kivelä R, Priest J; FinnGen; Palotie A, Ollila HM, Helle E. Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects. BMC Genomics. 2024 Mar 7;25(1):256. PMID: 38454350.

Burns K, Mullin BH, Moolhuijsen LME, Laisk T, Tyrmi JS, Cui J, Actkins KV, Louwers YV; Estonian Biobank Research Team; Davis LK, Dudbridge F, Azziz R, Goodarzi MO, Laivuori H, Mägi R, Visser JA, Laven JSE, Wilson SG; FinnGen; International PCOS Consortium; Day FR, Stuckey BGA. Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry. BMC Genomics. 2024 Feb 26;25(1):208. PMID: 38408933.

Elliott A, Walters RK, Pirinen M, Kurki M, Junna N, Goldstein JI, Reeve MP, Siirtola H, Lemmelä SM, Turley P, Lahtela E, Mehtonen J, Reis K, Elnahas AG, Reigo A, Palta P, Esko T, Mägi R; Estonian Biobank Research Team; FinnGen; Palotie A, Daly MJ, Widén E. Distinct and shared genetic architectures of gestational diabetes mellitus and type 2 diabetes. Nat Genet. 2024 Jan 5. Epub ahead of print. PMID: 38182742.

Heikkilä A, Sliz E, Huilaja L; FinnGen; Estonian Biobank Research Team; Reis K, Palta P, Elnahas AG, Reigo A, Esko T, Laisk T, Teder-Laving M, Tasanen K, Kettunen J. GENETIC STUDY OF PSORIASIS HIGHLIGHTS ITS CLOSE LINK WITH SOCIO-ECONOMIC STATUS AND AFFECTIVE SYMPTOMS. J Invest Dermatol. 2024 May 17:S0022-202X(24)00358-0. Epub ahead of print. PMID: 38763176.

Koch E, Kämpe A, Alver M, Sigurðarson S, Einarsson G, Partanen J, Smith RL, Jaholkowski P, Taipale H, Lähteenvuo M, Steen NE, Smeland OB, Djurovic S, Molden E; FinnGen; Estonian Biobank Research Team; Sigurdsson E, Stefánsson H, Stefánsson K, Palotie A, Milani L, O’Connell KS, Andreassen OA. Polygenic liability for antipsychotic dosage and polypharmacy – a real-world registry and biobank study. Neuropsychopharmacology. 2024 Jan 6. Epub ahead of print. PMID: 38184734.

Karjalainen MK, Karthikeyan S, Oliver-Williams C, Sliz E, Allara E, Fung WT, Surendran P, Zhang W, Jousilahti P, Kristiansson K, Salomaa V, Goodwin M, Hughes DA, Boehnke M, Fernandes Silva L, Yin X, Mahajan A, Neville MJ, van Zuydam NR, de Mutsert R, Li-Gao R, Mook-Kanamori DO, Demirkan A, Liu J, Noordam R, Trompet S, Chen Z, Kartsonaki C, Li L, Lin K, Hagenbeek FA, Hottenga JJ, Pool R, Ikram MA, van Meurs J, Haller T, Milaneschi Y, Kähönen M, Mishra PP, Joshi PK, Macdonald-Dunlop E, Mangino M, Zierer J, Acar IE, Hoyng CB, Lechanteur YTE, Franke L, Kurilshikov A, Zhernakova A, Beekman M, van den Akker EB, Kolcic I, Polasek O, Rudan I, Gieger C, Waldenberger M, Asselbergs FW; China Kadoorie Biobank Collaborative Group; Estonian Biobank Research Team; FinnGen; Hayward C, Fu J, den Hollander AI, Menni C, Spector TD, Wilson JF, Lehtimäki T, Raitakari OT, Penninx BWJH, Esko T, Walters RG, Jukema JW, Sattar N, Ghanbari M, Willems van Dijk K, Karpe F, McCarthy MI, Laakso M, Järvelin MR, Timpson NJ, Perola M, Kooner JS, Chambers JC, van Duijn C, Slagboom PE, Boomsma DI, Danesh J, Ala-Korpela M, Butterworth AS, Kettunen J. Genome-wide characterization of circulating metabolic biomarkers. Nature. 2024 Mar 6. Epub ahead of print. PMID: 38448586.

Krishna C, Tervi A, Saffern M, Wilson EA, Yoo SK, Mars N, Roudko V, Cho BA, Jones SE, Vaninov N, Selvan ME, Gümüş ZH; FinnGen§; Lenz TL, Merad M, Boffetta P, Martínez-Jiménez F, Ollila HM, Samstein RM, Chowell D. An immunogenetic basis for lung cancer risk. Science. 2024 Feb 23;383(6685):eadi3808. Epub 2024 Feb 23. PMID: 38386728.

Leinonen JT; FinnGen; Pirinen M, Tukiainen T. Disentangling the link between maternal influences on birth weight and disease risk in 36,211 genotyped mother-child pairs. Commun Biol. 2024 Feb 12;7(1):175. PMID: 38347176.

Loginovic P, Wang F, Li J, Ferrat L, Mirshahi UL, Rao HS, Petzold A, Tyrrell J, Green HD, Weedon MN, Ganna A, Tuomi T, Carey DJ; UKBB Eye & Vision Consortium; FinnGen; Geisinger-Regeneron DiscovEHR Collaboration; Oram RA, Braithwaite T. Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis. Nat Commun. 2024 Feb 28;15(1):1415. PMID: 38418465.

Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegoviç E, Babić D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C, Bierer LM, Biernacka JM, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Brandolino A, Breen G, Bressan RA, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum AD, Børte S, Cahn L, Calabrese JR, Caldas-de-Almeida JM, Chatzinakos C, Cheema S, Clouston SAP, Colodro-Conde L, Coombes BJ, Cruz-Fuentes CS, Dale AM, Dalvie S, Davis LK, Deckert J, Delahanty DL, Dennis MF, Desarnaud F, DiPietro CP, Disner SG, Docherty AR, Domschke K, Dyb G, Kulenović AD, Edenberg HJ, Evans A, Fabbri C, Fani N, Farrer LA, Feder A, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goleva SB, Gordon SD, Goçi A, Grasser LR, Guindalini C, Haas M, Hagenaars S, Hauser MA, Heath AC, Hemmings SMJ, Hesselbrock V, Hickie IB, Hogan K, Hougaard DM, Huang H, Huckins LM, Hveem K, Jakovljević M, Javanbakht A, Jenkins GD, Johnson J, Jones I, Jovanovic T, Karstoft KI, Kaufman ML, Kennedy JL, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kotov R, Kranzler HR, Krebs K, Kremen WS, Kuan PF, Lawford BR, Lebois LAM, Lehto K, Levey DF, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lu Y, Luft BJ, Lupton MK, Luykx JJ, Makotkine I, Maples-Keller JL, Marchese S, Marmar C, Martin NG, Martínez-Levy GA, McAloney K, McFarlane A, McLaughlin KA, McLean SA, Medland SE, Mehta D, Meyers J, Michopoulos V, Mikita EA, Milani L, Milberg W, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Mufford MS, Nelson EC, Nordentoft M, Norman SB, Nugent NR, O’Donnell M, Orcutt HK, Pan PM, Panizzon MS, Pathak GA, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Porjesz B, Powers A, Qin XJ, Ratanatharathorn A, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero KJ, Rung A, Runz H, Rutten BPF, de Viteri SS, Salum GA, Sampson L, Sanchez SE, Santoro M, Seah C, Seedat S, Seng JS, Shabalin A, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stensland S, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Tiwari AK, Trapido E, Uddin M, Ursano RJ, Valdimarsdóttir U, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt FR, Werge T, Williams MA, Williamson DE, Winsvold BS, Winternitz S, Wolf C, Wolf EJ, Xia Y, Xiong Y, Yehuda R, Young KA, Young RM, Zai CC, Zai GC, Zervas M, Zhao H, Zoellner LA, Zwart JA, deRoon-Cassini T, van Rooij SJH, van den Heuvel LL; AURORA Study; Estonian Biobank Research Team; FinnGen Investigators; HUNT All-In Psychiatry; Stein MB, Ressler KJ, Koenen KC. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nat Genet. 2024 Apr 18. Epub ahead of print. PMID: 38637617.

Nurkkala JM, Aittokallio J; FinnGen; Kauko A, Niiranen T. Sex-Specific Genetic Risks for Adverse Outcomes After Coronary Revascularization Procedures. Interdiscip Cardiovasc Thorac Surg. 2024 Jan 12:ivae006. Epub ahead of print. PMID: 38216540.

Pasanen A, Sliz E, Huilaja L; FinnGen; Estonian Biobank Research Team; Reimann E, Mägi R, Laisk T, Tasanen K, Kettunen J. Identifying atopic dermatitis risk loci in 1,094,060 individuals with sub analysis of disease severity and onset. J Invest Dermatol. 2024 Apr 23:S0022-202X(24)00285-9. Epub ahead of print. PMID: 38663478.

Pirruccello JP, Di Achille P, Choi SH, Rämö JT, Khurshid S, Nekoui M, Jurgens SJ, Nauffal V, Kany S; FinnGen; Ng K, Friedman SF, Batra P, Lunetta KL, Palotie A, Philippakis AA, Ho JE, Lubitz SA, Ellinor PT. Deep learning of left atrial structure and function provides link to atrial fibrillation risk. Nat Commun. 2024 May 21;15(1):4304. PMID: 38773065.

Purdue MP, Dutta D, Machiela MJ, Gorman BR, Winter T, Okuhara D, Cleland S, Ferreiro-Iglesias A, Scheet P, Liu A, Wu C, Antwi SO, Larkin J, Zequi SC, Sun M, Hikino K, Hajiran A, Lawson KA, Cárcano F, Blanchet O, Shuch B, Nepple KG, Margue G, Sundi D, Diver WR, Folgueira MAAK, van Bokhoven A, Neffa F, Brown KM, Hofmann JN, Rhee J, Yeager M, Cole NR, Hicks BD, Manning MR, Hutchinson AA, Rothman N, Huang WY, Linehan WM, Lori A, Ferragu M, Zidane-Marinnes M, Serrano SV, Magnabosco WJ; BioBank Japan Project; Vilas A, Decia R, Carusso F, Graham LS, Anderson K, Bilen MA, Arciero C, Pellegrin I, Ricard S; FinnGen; Scelo G, Banks RE, Vasudev NS, Soomro N, Stewart GD, Adeyoju A, Bromage S, Hrouda D, Gibbons N, Patel P, Sullivan M, Protheroe A, Nugent FI, Fournier MJ, Zhang X, Martin LJ, Komisarenko M, Eisen T, Cunningham SA, Connolly DC, Uzzo RG, Zaridze D, Mukeria A, Holcatova I, Hornakova A, Foretova L, Janout V, Mates D, Jinga V, Rascu S, Mijuskovic M, Savic S, Milosavljevic S, Gaborieau V, Abedi-Ardekani B, McKay J, Johansson M, Phouthavongsy L, Hayman L, Li J, Lungu I, Bezerra SM, Souza AG, Sares CTG, Reis RB, Gallucci FP, Cordeiro MD, Pomerantz M, Lee GM, Freedman ML, Jeong A, Greenberg SE, Sanchez A, Thompson RH, Sharma V, Thiel DD, Ball CT, Abreu D, Lam ET, Nahas WC, Master VA, Patel AV, Bernhard JC, Freedman ND, Bigot P, Reis RM, Colli LM, Finelli A, Manley BJ, Terao C, Choueiri TK, Carraro DM, Houlston R, Eckel-Passow JE, Abbosh PH, Ganna A, Brennan P, Gu J, Chanock SJ. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions. Nat Genet. 2024 Apr 26. Epub ahead of print. PMID: 38671320.

Rämö JT, Kany S, Hou CR, Friedman SF, Roselli C, Nauffal V, Koyama S, Karjalainen J, Maddah M, Palotie A, Ellinor PT, Pirruccello JP; FinnGen. Cardiovascular Significance and Genetics of Epicardial and Pericardial Adiposity. JAMA Cardiol. 2024 Mar 13:e240080. doi: 10.1001/jamacardio.2024.0080. Epub ahead of print. PMID: 38477908.

Strausz S, Abner E, Blacker G, Galloway S, Hansen P, Feng Q, Lee BT, Jones SE, Haapaniemi H, Raak S, Nahass GR, Sanders E; FinnGen; Estonian Genome Centre; Estonian Biobank Research Team; Soodla P, Võsa U, Esko T, Sinnott-Armstrong N, Weissman IL, Daly M, Aivelo T, Tal MC, Ollila HM. SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease. Nat Commun. 2024 Mar 19;15(1):2041. PMID: 38503741.

Tamlander M, Jermy B, Seppälä TT, Färkkilä M; FinnGen; Widén E, Ripatti S, Mars N. Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening. Br J Cancer. 2024 Mar;130(4):651-659. Epub 2024 Jan 3. PMID: 38172535.

Youssef O, Loukola A, Zidi-Mouaffak YHS, Tamlander M, Ruotsalainen S, Kilpeläinen E, Mars N, Ripatti S; FinnGen; Palotie A, Donner K, Carpén O. High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases. Lab Invest. 2024 Apr;104(4):100325. Epub 2024 Jan 14. PMID: 38220043.